Chiefs vs. Jaguars prediction, odds, spread, injuries, trends for NFL Week 2

Full betting preview for the Kansas City Chiefs and Jacksonville Jaguars in NFL Week 2.

Chiefs quarterback Patrick Mahomes
Chiefs quarterback Patrick Mahomes / Junfu Han / USA TODAY NETWORK

The Jacksonville Jaguars nearly had the Kansas City Chiefs on the ropes in the divisional round of the playoffs last season, but a one-legged Patrick Mahomes pulled it out for KC on their way to the Super Bowl. Now, after taking care of the Colts to get to 1-0, Trevor Lawrence and the Jaguars have a shot at revenge as they host the 0-1 Chiefs in Week 2. 

Kansas City had a few extra days to figure things out after losing to Detroit, but more importantly, extra time for Travis Kelce to get healthy after missing their season opener, and to get Chris Jones signed. Kelce is still questionable, but Chris Jones is signed and probable to play. With that, the Chiefs are favored on the road. 

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Chiefs vs. Jaguars odds, spread and total 

Jaguars vs. Chiefs Betting Trends

  • Jaguars are 1-0 ATS
  • The OVER is 1-0 in Jaguars games
  • Chiefs are 0-1 ATS
  • The UNDER is 1-0 in Chiefs games
  • The UNDER is 4-1 in the Chiefs' last five games
  • Chiefs are 6-2 ATS in their last eight games vs. Jaguars
  • Jaguars are 7-1 ATS in their last eight games

Chiefs vs. Jaguars injury reports

Chiefs injury report

  • Chris Jones - DT - Probable (Holdout)
  • BJ Thompson - DE - Questionable (hamstring)
  • Nic Jones - CB - Questionable (hand)
  • Travis Kelce - TE - Questionable (knee)

Jaguars injury report

  • Tyler Lacy - DE - Questionable (hip)
  • Antonio Johnson - S - Questionable (hamstring)
  • Brandon Scherff - OL - Questionable (ankle)
  • Gregory Junior - CB - Questionable (hamstring)

Chiefs vs. Jaguars how to watch

  • Date: Sunday, September 17
  • Time: 1:00 PM EST
  • Venue: EverBank Stadium
  • How to Watch (TV): CBS
  • Chiefs Record: 0-1
  • Jaguars Record: 1-0

Chiefs vs. Jaguars key players to watch


Isiah Pacheco, RB: Last year, the Chiefs won the Super Bowl by leaning into the running game, but in Week 1 they didn’t go back to it against Detroit. Patrick Mahomes was the team’s leading rusher going for 45 yards on six carries. Pacheco had just 23 yards on eight carries, and while there are still issues at wide receiver for this team they may need to hand it off a few more times to their second-year back. 


Christian Kirk, WR: In 2022, Kirk was the lead receiver for Trevor Lawrence. He went for 1,108 yards and eight touchdowns on 84 receptions, but in Week 1 of 2023 he only had one grab for nine yards. With the addition of Calvin Ridley, it seems Kirk is taking more of a backseat, so his involvement will be something to monitor considering he counts for $11.4 million on the cap this year and then $24.4 million in 2024 and 2025. 

Chiefs vs. Jaguars prediction and pick

Andy Reid has a great record coming off a bye week, but with a simple rest advantage, like they have coming into Week 2, his team’s in Kansas City are just 19-20 against the spread since 2013. Since 2017 (when Patrick Mahomes took over) with a rest advantage they are 14-15 against the spread, so there isn’t a gambling advantage there. 

In 2022, the Jaguars were 27th in passing yards allowed, giving up 238.2 a game. Their secondary is the weakness of this team and despite Kansas City’s lack of receivers, Patrick Mahomes is going to figure it out. Kadarius Toney was actively trying to lose Week 1 and with a little less on his shoulders and with him a bit more comfortable after missing most of training camp, the Chiefs passing game should be okay. Rashee Rice was promising with his three catches for 29 yards and a touchdown. He may be their best receiver by season’s end. 

The thing about Kansas City in Week 1 is that their defense actually carried them. The defense only allowed 14 points because the other touchdown was a Mahomes pick-six. Detroit gained 5.3 yards per play which ranked ninth in Week 1, but would have been 17th in 2022. That was without Chris Jones in the middle, so with Jones back this defense will get even better and I like Kansas City to bounce back. 

The Chiefs are 6-2 against the spread in their last eight head-to-head matchups with the Jaguars. 

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Game odds refresh periodically and are subject to change