Mr. Irrelevant is the brainchild of former NFL player Paul Salata, and Harnish is the 37th man to earn the title.
And some of the previous winners actually have proven to be quite relevant.
Bill Kenney, who earned the award as the second-to-last player taken in 1978 after the final selection suffered an injury and did not report to camp, became a Pro Bowler in 1983 with the Kansas City Chiefs.
Special-teamer Marty Moore won a Super Bowl ring with the New England Patriots in 2001, and St. Louis linebacker David Vobora and Chiefs kicker Ryan Succop are current starters in the NFL.
The Colts even had their own brief brush with Mr. Irrelevant success with fullback Jim Finn — who was taken by the Chicago Bears in 1999, played in Indianapolis from 2000-02 and became a starter with the New York Giants between 2003-06.